Zanaflex (Tizanidine dosage) 4mg pills/tablets
Zanaflex (Tizanidine dosage) treats muscle spas
Usual Adult Dose for Muscle Spasm
Initial dose of Tizanidine dosage: 2 mg orally every 6 to 8 hours as needed
-Peak effects occur in approximately 1 to 2 hours and last for 3 to 6 hours treatment can be repeated as needed to a maximum of 3 doses in 24 hours; gradually increase dose by 2 to 4 mg at intervals of 1 to 4 days until satisfactory reduction of muscle tone is achieved.
Maximum single dose: 16 mg
Maximum daily dose: 36 mg in 24 hours
-Clinically significant differences in absorption are expected between capsules and tablets when taken with or without food; these differences could result in changes in efficacy and tolerability.
-Once a formulation is decided on and a decision is made to take with or without food, this regimen should not be altered.
>Use: Management of spasticity.
Renal Dose Adjustments
Severe renal impairment (CrCl less than 25 mL/min): Individualize therapy with lower doses during dose titration; if higher doses are required, individual doses should be increased rather increasing the dosing frequency; closely monitor for toxicity
Liver Dose Adjustments
Use with caution in elderly patients, especially those with renal impairment.
-Decrease by 2 to 4 mg per day, especially in patients who have been receiving doses of 20 to 36 mg per day for periods of 9 weeks or more.
Safety and efficacy have not been established in patients younger than 18 years.
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